Impaired DNA replication can cause epigenetic changes. Genome-wide epigenetic alterations establish new gene expression states that may be inherited for up-to five generationsm meaning that two individuals may differ in gene expression only because of the stress experienced by their ancestors.

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Impaired DNA replication can cause epigenetic changes. Genome-wide epigenetic alterations establish new gene expression states that may be inherited for up-to five generationsm meaning that two individuals may differ in gene expression only because of the stress experienced by their ancestors.