Caloric restriction (a 30% reduction in daily intake) or single-meal feeding (resulting in fasting during each day but no caloric restriction) increased life span and delayed the onset of age-associated pathologies in mice compared with ad libitum feeding.

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Caloric restriction (a 30% reduction in daily intake) or single-meal feeding (resulting in fasting during each day but no caloric restriction) increased life span and delayed the onset of age-associated pathologies in mice compared with ad libitum feeding.