Hi Reddit,
My name is Igor Korolev, and I am a resident physician in psychiatry at the University of Miami/Jackson Memorial Hospital (previously a D.O./Ph.D. candidate at Michigan State University). My research focuses on using various methods such as neuroimaging and cognitive tests to develop novel approaches for the early detection of Alzheimer's disease (or alternatively for identification of people at risk for developing dementia due to Alzheimer's disease).
I am the lead author of a research article titled, "Predicting Progression from Mild Cognitive Impairment to Alzheimer's Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification", published in the journal PLOS ONE. This work was co-authored with my mentors, Andrea Bozoki, an academic neurologist, and Laura Symonds, a neuroscientist, at Michigan State University.
Mild cognitive impairment (MCI) is considered to be a transitional phase between normal cognitive aging and dementia. We used data from the Alzheimer's Disease Neuroimaging Initiative and computer algorithms (referred to as machine learning) to design a model for predicting whether a person with MCI will develop dementia due to Alzheimer's disease over a three-year period. Our model was able to predict future progression from MCI to Alzheimer's-type dementia with 80% accuracy using information from cognitive and functional assessments and brain magnetic resonance imaging (MRI) scans. The model utilizes widely available, cost-effective, non-invasive methods and can be used to improve patient selection in clinical trials of Alzheimer's disease therapies as well as to identify high-risk MCI patients for early treatment.
I'll be answering your questions at 1pm ET -- Ask Me Anything!
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