PLOS Science Wednesday: Hi Reddit, my name is Alan Garfinkel and I developed an electrophysiology model of heart failure that shows certain cellular conditions in the heart may be predispose people to cardiac death – Ask Me Anything!

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Hi Reddit,

My name is Alan Garfinkel and I am Professor of Medicine (Cardiology) at UCLA. My research focuses on the use of mathematical models of cellular and tissue electrophysiology of the heat, especially on the causes of cardiac arrhythmias.

I recently published an article “Electrophysiology of Heart Failure Using a Rabbit Model: From the Failing Myocyte to Ventricular Fibrillation” in PLOS Computational Biology. Previously, I had published an article “Simulation methods and validation criteria for modeling cardiac ventricular electrophysiology”.

Both papers use a large-scale model of electrical conduction in the heart. The PLOS ONE paper addresses the question of verification of a whole heart electrophysiology model: what reality criteria does a model have to meet? We propose a series of these, and describe a model that satisfies them.

The PLOS Computational Biology paper develops this model, and creates a version modeling the electrophysiology of heart failure. We show that the altered cellular conditions known to be present in heart failure predispose the heart to a greater risk of ventricular fibrillation, the leading cause of sudden cardiac death.

See also Xie, F., Qu, Z., Yang, J., Baher, A., Weiss, J. N., & Garfinkel, A. (2004). A simulation study of the effects of cardiac anatomy in ventricular fibrillation. The Journal of Clinical Investigation.

I will be answering your questions at 1pm ET -- Ask Me Anything!

">PLOS Science Wednesday: Hi Reddit, my name is Alan Garfinkel and I developed an electrophysiology model of heart failure that shows certain cellular conditions in the heart may be predispose people to cardiac death – Ask Me Anything!