Up to 50% of people with pathological signs of Alzheimer's disease do not develop dementia. This has prompted a search for mechanisms of cognitive resilience. A new study shows that dendritic spines provide such resistance, suggesting that targeting dendritic spine plasticity may ameliorate AD.

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Up to 50% of people with pathological signs of Alzheimer's disease do not develop dementia. This has prompted a search for mechanisms of cognitive resilience. A new study shows that dendritic spines provide such resistance, suggesting that targeting dendritic spine plasticity may ameliorate AD.