The Cas9 protein of the CRISPR system may not be well tolerated by the human body in its native form as it is of bacterial origin, limiting its applications in gene therapy. Now scientists have slightly modified Cas9 at two locations, making it immunologically silent while preserving its function.

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The Cas9 protein of the CRISPR system may not be well tolerated by the human body in its native form as it is of bacterial origin, limiting its applications in gene therapy. Now scientists have slightly modified Cas9 at two locations, making it immunologically silent while preserving its function.