Science AMA Series: I’m Susanna Rosi, director of neurocognitive research at UCSF. I study brain injury and how trauma impacts cognitive function. My lab just released findings on a drug-like molecule that reverses cognitive impairment in mice with traumatic brain injury. AMA!

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Hi Reddit, I’m Susanna Rosi and I’m interested in understanding why our brain loses the ability to learn and form new memories. One of the models we investigate is physical trauma, such as concussions, that can lead to long-term and sometimes permanent changes in memory. Recently, my team has been working with a drug-like compound called ISRIB, which has been shown to have protective and restorative effects on cognition. In our recent studies of mice that received a traumatic brain injury, a dose of ISRIB administered even weeks after trauma was able to restore the mouse’s ability to perform memory-related tasks.

Here’s an article UCSF produced about my latest research: http://ift.tt/2vp0t7b

I’m interested in the molecular basis of injury-induced dementia, the contributions of different cell types (neurons, microglia, astrocytes, infiltrating leucocytes) to cognitive deficits, and compounds that could protect or even enhance cognition. I will be back at 1 pm ET to answer your questions, Ask me anything!

">Science AMA Series: I’m Susanna Rosi, director of neurocognitive research at UCSF. I study brain injury and how trauma impacts cognitive function. My lab just released findings on a drug-like molecule that reverses cognitive impairment in mice with traumatic brain injury. AMA!