One of the first studies to explore the effects of calorie restriction on humans showed that cutting caloric intake by 15% for 2 years in healthy, non-obese adults slowed aging and metabolism and protected against age-related disease.

See the source article by following the link below:
One of the first studies to explore the effects of calorie restriction on humans showed that cutting caloric intake by 15% for 2 years in healthy, non-obese adults slowed aging and metabolism and protected against age-related disease.